"Uncertain" Genetic Test Result

An uncertain, or "variant of uncertain clinical significance (VUS)" result means:

• The test identified a variation in a gene, but we don’t know enough about this variation to determine whether it's normal or not.
• The variation has not yet been linked to cancer, but a link hasn’t been ruled out.
• Most variants of uncertain significance eventually are found to be benign (harmless) changes, but not always.

What do I do if my results are VUS, or uncertain?

Talk with your genetic counselor or provider about how to stay informed about any changes or updates to the classification of your variant. Additional cancer screening might be recommended based on family history.